Polynucleotides

Benefits of Polynucleotides

Reduce the appearance of fine lines and wrinkles

Improve hydration and skin elasticity

Stimulate fibroblasts to boost collagen and elastin production

Suitable for delicate areas such as the under-eyes as well as the face, neck, and décolletage

Calm inflammation and improve skin health

Help repair sun-damaged or stressed skin

The Treatment

Polynucleotides are delivered via a series of small, precise injections into the skin. Once placed, they trigger a natural cascade of repair processes — encouraging skin cells to regenerate and remodel from the inside out.

A course of treatments is usually recommended for optimal results, with improvements continuing to develop gradually in the weeks and months that follow. The treatment is well tolerated and requires little to no downtime.

Ready to renew your skin?

Prices start from £225

Polynucleotides are highly purified DNA fragments derived from natural sources. They stimulate skin repair and regeneration, improving overall skin quality. They have been nicknamed the “salmon sperm facial” in the media, as early research extracted DNA from salmon, but the products used in clinic today are rigorously purified, sterile, and safe for aesthetic use.

What are polynucleotides?

FAQ's

Once injected, polynucleotides encourage fibroblasts (the cells responsible for collagen and elastin production) to activate. They also improve hydration, calm inflammation, and boost cell turnover — leaving skin healthier, firmer, and more radiant.

How do polynucleotides work?

Polynucleotides are suitable for many areas, including:

• Under-eyes (for dark circles, hollows, and crepey skin)

• Full face (for texture, elasticity, and fine lines)

• Neck and décolletage

• Hands and other areas with sun damage or signs of ageing

Which areas can be treated?

A course of 3–4 treatments spaced 2–4 weeks apart is usually recommended to achieve optimal results. Maintenance sessions can then be performed every 6–12 months.

How many sessions will I need?

There may be mild redness or small bumps at the injection sites immediately after treatment, but these usually settle within 24–48 hours. Most people return to normal activities the same day.

Is there any downtime?

Improvements are gradual, as the skin regenerates over time. Many clients begin to notice brighter, healthier skin within a few weeks, with further improvements developing in the months that follow.

When will I see results?

Yes. Polynucleotide treatments used in aesthetics are sterile, highly purified, and supported by clinical research. As with all injectable treatments, they should only be administered by a qualified medical professional.

Are polynucleotides safe?

Absolutely. They are often combined with treatments such as microneedling, radiofrequency, or dermal fillers to further enhance results. Your treatment plan will be tailored to your specific needs and goals.

Can polynucleotides be combined with other treatments?

• Small bumps, redness, or slight swelling at the injection sites are normal and usually settle within 24–48 hours.

• Avoid touching, rubbing, or applying pressure to the treated areas.

• If needed, a cool compress may be applied, but avoid placing ice directly on the skin.

Immediately after treatment:

• Avoid applying makeup to the treated areas.

For the first 12 hours:

Aftercare Advice – Polynucleotides

To achieve the best results and support your skin’s natural regeneration, please follow the guidance below after your polynucleotide treatment:

• Avoid strenuous exercise, alcohol, and excessive caffeine.

• Refrain from exposure to heat such as hot baths, saunas, and steam rooms.

For the first 24 hours:

• Avoid facials, massage, or treatments that apply pressure to the skin.

• Sleep on your back where possible to minimise pressure on the treated areas.

For the first 48 hours:

• Stay well hydrated and maintain a good skincare routine to support results.

• The treatment works gradually, with improvements continuing over the following weeks and months.

• If you experience prolonged redness, pain, or any unexpected symptoms, please contact the clinic immediately.

General Guidance

• Protect your skin from direct sunlight. Always use a high SPF and avoid sunbeds.

• Postpone any skin treatments such as peels, microneedling, or laser until advised it is safe to continue.

For the first week: